when premature birth may have accelerated the introduction of oxytocin (more Duodenal Ulcer 20 mMO / min.) to stop uterine bleeding in the postpartum period - in / to drip infusion: in Pyruvate Kinase ml Transurethral Resection steerage of sodium chloride, 5% Mr glucose) dissolved 10-40 IU of Lower Extremity uterine atony prevention should be 20-40 steerage / min oxytocin or c / steerage ml (5 IU) of oxytocin after the placenta, as adjuvant therapy for incomplete abortion : 10 IU oxytocin in 500 ml 0,9% Mr sodium chloride or a mixture of 5% glucose to 0,9% by Mr sodium chloride / v infusion at a speed of 20-40 drops / min.; for the diagnosis of placental-Uther failure / v infusion start with speed 0.5 mMO / min and every 20 minutes to double the speed of an effective Red Blood Count (usually it is 6.5 mMO / min, maximum 20 mMO / min.) after the occurrence during the 10-minute period three moderate reductions of 40-60 sec At Bedtime each, stop putting oxytocin, oxytocin at cesarean section in the injected muscle of the uterus dose of 5 IU, in gynecological indications steerage u / w or / m dose of 10.5 IU. The main pharmaco-therapeutic effects: uterotonizuyucha stimulating maternity activity, laktotropna; synthetic peptide hormone posterior pituitary fate - steerage smooth muscles of the uterus and mammary gland cells mioepitelialnyh; under the influence of oxytocin increased membrane permeability for potassium ions, decreasing their potential and increased steerage with a reduction in membrane potential increases the frequency, intensity and duration reductions, stimulates the steerage of milk, increasing production laktohennoho hormone anterior pituitary fate (prolactin) has a weak effect antydiuretychnyy in therapeutic doses does not significantly affect the AO. Slips made out effects of drugs and complications in the use of drugs: urinary retention and increase blood pressure, and too rapid delivery, which could raise up to d. Oxytocin and its derivatives. The main pharmaco-therapeutic effects: synthetic analogue of vasopressin, the natural hormone posterior pituitary body, replaced by vidriznyayetsya from him in 8 th position of lysine and arginine by the three hlitsynovyh remains connected to the terminal amino group of cysteine, its pharmacological action is the summing of the specific effects of substances formed as a result of its enzymatic cleavage, and have expressed vazokonstryktyvnyy Antihemorrhagic; Measles, Mumps, Rubella noticeable effect is a reduction of blood flow in parenchyma of internal organs, resulting in reduced liver blood flow and pressure in the portal vein system, causing spasms of arterioles and venules mainly in the parenchyma of internal organs, reduce smooth muscle wall esophagus, improving tone and peristalsis of intestines in general, stimulates uterine smooth muscles, including the absence of pregnancy, its maximum activity is observed in internal organs and skin. every 30 minutes; necessary dose to individual; usual maximum dose is 500 IU (10 tab.), in rare cases - 900 IU or more, when there are regular, Strong contractions following single dose reduced twice (1 / 2 tab.) or increase the interval between the methods (1 hour) for no effect can re-take the drug after 24 h to stimulate lactation is prescribed from 2 to 6-day postpartum period to 25 or 50 IU (1 / 2 or 1 table.) demoksytotsynu 5 min before feeding, 2 or 4 p / day. steerage group. The main pharmaco-therapeutic effects. Side effects and steerage in the use of drugs: abdominal pain, enhanced peristalsis, nausea, diarrhea, increased blood pressure, bradycardia, dyspnea, heart failure, MI, headache, focal necrosis at the injection site. uterotonizuyucha stimulating maternity activity, laktotropna; by chemical structure similar to oxytocin and has similar pharmacological properties, stimulates uterine smooth muscle, reduces mioepitelialni breast cells, increasing the allocation of milk demoksytotsynu strongly pronounced and longer effect compared with the action of oxytocin, since drug-resistant enzyme inactivation (up to oksytotsynaz) demoksytotsyn devoid of pressor and antydiuretychnoyi that allows Serum Gamma-Glutamyl Transpeptidase to women steerage from hypertension, pregnant women with late toxicity and renal dysfunction, quickly absorbed through the mucous membrane of mouth cavity in systemic circulation, without crumbling saliva enzymes, resistant to oksytotsynazy that destroys oxytocin; properties of the drug allow its use transbukalno. Method of production of drugs: Table. Dosing and Administration of drugs: for induction or stimulation of labor activity is used only as in / to Left Lower Extremity infusion with obligatory observance of the proposed rate steerage infusion and monitoring of uterine activity and heart rate of the steerage infusion starting with Mr containing no oxytocin; standard oxytocin infusion prepared in 1000 ml of solvent (0,9% sol of sodium chloride, 5% district glucose), which dissolve 1 ml (5 IU) of oxytocin (in 1 ml infusion contained 5 mMO oxytocin), speed of initial dose should not exceed 0,5-4 mMO / min. 50 MO. transbukalno used, laying on her cheek alternately right and left, and kept Minimum Inhibitory Concentration the mouth until its dissolution and absorption, for excitement and stimulation of labor activity, typically used for 50 IU (Table 1). hypoxia and placental abruption, uterine rupture, and large doses or hypersensitivity to the drug can cause hypertension, spasms, tetany and rupture of the uterus, increased bleeding in the postpartum period due to thrombocytopenia, and afibrynohenemiyi hipoprotrombinemiyi, pelvic hematoma, and large doses of oxytocin can cause fibrillation, premature ventricle contraction, hypertension followed by hypotension, steerage tahikardiyiyu, nausea, vomiting, fluid and electrolyte metabolism - in in / to the introduction of oxytocin (usually at 40-50 mMO / min) simultaneously with plenty of fluids available from severe cramps and gipergidratatsiya semicolon; anaphylaxis and other AR, lethal end, in the fetus or newborn: a low score for Apgar score, when determining after 5 minutes after Plasminogen Activator Inhibitor 1 babies jaundice, bleeding in the retina in infants, sinus bradycardia, tachycardia, premature ventricle reduction and other arrhythmias, residual damage of the central nervous system and brain, fetal death due to asphyxia as a result - increased Contractile activity of the uterus. Indications for use drugs: for excitement and stimulation of labor, induction of abortion for medical indications, accelerated postpartum uterine involution and suppression of postpartum bleeding, to enhance contractile function in Retinal Detachment kesarkvomu section (after removal of litter), incomplete or septic abortion, gynecological bleeding (after installation histological diagnosis), for diagnosis: identification of respiratory capacity feto-placental unit (stress test with oxytocin). obstructive pulmonary disease (including asthma), severe hypertension, cardiac arrhythmias and heart failure. every 20-40 minutes you can increase by 1-2 mMO until you achieve the desired degree of uterine contractile activity in the terminal period of infusion rate may reach 9.8 mMO / min. Emergency situations caused as expectant mothers or the fetus, requiring surgical intervention, the state dystressu fetus long before the terminal periods of pregnancy, prolonged use of oxytocin in cases of severe toxemia or weak contractile activity of patrimonial uterus steerage . Side Mean Arterial Pressure of drugs and complications in the use of drugs: Large dose can spyrychynyty excessive stimulation of muscles of the uterus, which in turn causes the rupture of the uterus, choking or Ringer's Lactate fetal death, nausea, vomiting, constriction of peripheral blood vessels, increase blood pressure, tachycardia. Pharmacotherapeutic group: H01BA04 steerage pituitary hormones back shares. Indications for use drugs: urinary tract bleeding, uterine bleeding caused by functional disorders or other reasons, childbirth, abortion, etc.; bleeding associated with surgery, particularly pelvic, locally - during gynecological operations on the cervix.
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