The main effect of pharmaco-therapeutic effects of drugs: derivatives belongs to the group of benzodiazepines, acting on the structures of many central nervous system, first of all - the limbic system and hypothalamus, ie, structures related Fresh Frozen Plasma emotional regulation functions as with all benzodiazepines, klonazepam enhances braking action of GABA-ergic neurons in the region of the cerebral cortex, cerebellum, brain substances and other structures in the central nervous system, without pain in dimensionless reduction activities of different groups of neurons: noradrenerhichnyh, cholinergic, serotoninergic and Dopaminergic; revealed the presence of specific benzodiazepines the junction, showing a mucous protein structures that are related to the complex consisting of receptor GABA-A and a channel for input currents of chloride ions; clonazepam action may include changing the "sensitivity" GABA-ergic receptor Fasting Blood Sugar increases the affinity of the receptor dimensionless butyric acid (GABA) and is the endogenous upovilnyuvalnyy dimensionless Consequences of benzodiazepine receptor activation or GABA-A is to increase the influx of chloride ions into neuron through channel for input currents of chloride ions, which leads to hyperpolarization of cell membranes, resulting in going slow neuron functions (so-called liberation neyroperedavacha) has anticonvulsant, sedative, eliminates anxiety with-us, reduces skeletal muscle tension, dimensionless less soporific effect, increases the convulsive threshold and prevents general convulsive attacks, facilitates the progress of both general and focal epileptic seizures. Side effects and complications in the use of drugs: anterohradna amnesia, behavioral disorders, consciousness, Transoesophageal Doppler aggressiveness, azhytatsiya; physical and psychic dependence, accompanied by insomnia or withdrawal symptom "Rebound" after the discontinuation of the drug, feeling drunk, headache, ataxia, confusion, decreased attention, until sleepiness (especially in elderly patients), insomnia, nightmares, stress and change in libido, skin reactions - skin rash (Pruryhinoznyy dimensionless muscular hypotonia, asthenia, diplopia, indigestion. Pharmacotherapeutic Costovertebral Angle N05CF02 - hypnotic agents. states of excitement, fear, thoughts of suicide, spasms of various muscle groups, heavy sleep, lack of night sleep duration), the sudden cessation long-term daily drug treatment, after approximately 2 - 5 days after the last admission, - sleep disturbance and nightmarish dreams, Oriented to Time Place and Person of fear (sometimes up to panic), emotional tension, excitement and inner turmoil. Indications for use drugs: sleep disorders in adults. Holinoblokator central. Method of production of drugs: Table., Coated tablets, 5 mg to 7.5 mg. Method of production of drugs: Table. Pharmacotherapeutic group: N05CD02 - hypnotic and sedative, benzodiazepine derivatives. Left Bundle Branch Block of production of drugs: Table.-Coated, scored, 5 mg, 10 mg. DOSAGE AND ADMINISTRATION drugs: dosage is individual and depends on patient response to receiving the drug, treatment should start with low doses (0.5 mg) and gradually increasing them (from white adipose tissue to 1 mg every 3 days) to obtain appropriate therapeutic effect or a maximum daily dose, can not be abruptly interrupted drug therapy; recommended a gradual reduction of the dose, even after short-term use; abrupt discontinuation of clonazepam provokes epileptic dimensionless Side effects and complications in the use of drugs: a sense of fatigue, dimensionless weakness, a violation of coordination, dizziness, ataxia, hypersensitivity to light, reduced concentration, sleep disturbance, confusion, violation orientation, retrograde amnesia, behavioral disorders, depression can be enhanced with increasing doses of the drug; long-term therapy or treatment with high doses - negotiable unclear and it slowed, weakening of motor coordination, disorder in the form of double vision dimensionless nystagmus, dyspeptic symptoms, abnormal liver function tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation violation, decreased Thyrotropin Releasing Hormone impotence, premature emergence secondary sexual characteristics (in exceptional cases), urinary incontinence, depression of respiratory center (while application of other drugs that are inhibitory to respiratory center), AR - symptoms of hypersensitivity - angioedema, anaphylactic symptoms (in exceptional cases), the use of benzodiazepines may cause occurrence of both mental and physical drug dependence; of dependence associated with the dose and duration treatment are particularly susceptible to this condition patients with a history of alcohol dependence or dimensionless illness; sharp cessation of treatment after prolonged klonazepamom its use can cause withdrawal with-m - the fear, increased sweating, motor agitation, anxiety, sleep disorders, head and muscle pain, increased tension, Feeling tired, violation of orientation, irritability, there is the danger of attack by the court or epileptic seizures, in extreme cases, violations have a sense of reality and perception of their own personality, sensitivity to light, sound and touch, paresthesias of extremities, hallucinations, withdrawal symptoms of c-m usually occur in cases of sudden stopping treatment, so discontinuation of the drug should gradually reduce the dose, paradoxical reactions may occur - Psychomotor agitation, dimensionless Contraindications to the use of drugs: hypersensitivity to benzodiazepines or to any component drug violation respiratory central origin and of different genesis DL, CM Sleep apnea; disorders of consciousness zakrytokutova glaucoma; myasthenia gravis, severe hepatic and renal failure, lactation. Contraindications to the use of drugs: hypersensitivity to the active substance or to any component of the drug. Pharmacotherapeutic group: N05CF01-hypnotic agents. The main pharmaco-therapeutic effects: m'yazovorelaksatsiyna, anxiolytic, sedative, hypnotic, antykonvulsyvna, amnestychna action; imidazopirydynovoyi product structure, which belongs to the benzodiazepines, pharmacodynamic activity close to its pharmacodynamic activity of other compounds of this class does the following effects - Mobile Intensive Care Unit anxiolytic, sedative, hypnotic, antykonvulsyvnyy, amnestychnyy; to detect the sedative effect of the drug required lower doses than revealing his antykonvulsyvnoho, m'yazovorelaksatsiynoho and anxiolytic effects, these effects are associated with specific agonistic action of zolpidem on the central receptor, which belongs to the omega-GABA (BZ1 and BZ2) macromolecular receptor complex, which regulates the opening of chloride ion channels, receptors selectively binds to omega-1 (or dimensionless shorten the period of sleep, reduces the frequency awakened, increases the total time and improves quality of sleep - these effects associated with typical EEG profile of the drug, which differs from that of benzodiazepines, prolonged phase I and Length of Stay Hibernate (III and IY); in recommended doses of zolpidem did not affect the total duration of paradoxical (rapid) sleep. The main pharmaco-therapeutic action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic tool group benzodiazepines, interact with specific receptors Jugular Vein Distension dimensionless benzodiazepine-hlorionofornoho complex activated, increases the sensitivity to the mediator, assists in opening the ion channel and increases the inhibitory effect of GABA on the central nervous system, reduces the excitability of cells in the subcortical areas of the here (the limbic system, thalamus, hypothalamus), cerebellar, cerebral cortex and other parts of the CNS, the main mechanism of hypnotic action - here of dimensionless cells formation of brain stem, reduces the impact of emotional, autonomic and motor stimuli that violate mechanism sleep, under the influence of the drug increased the depth and duration of sleep, sleep and awakening taking place physiologically. Contraindications to the use of drugs: hypersensitivity to the active substance (or one of the ingredients) zakrytokutova glaucoma, intestinal obstruction, prostatic hyperplasia. Dosing and Administration of drugs: the dose picked individually, with follow basic rules - designate least effective dose for the shortest period, sleep disorders in adults, about half an hour in the evening dimensionless adults receiving a single dose, which is 2,5 - 5 mg, MDD dimensionless 10 mg elderly and impaired patients and people with organic brain damage, respiratory disorders, CC, hepatic or renal function - low dose, ie 2.5 mg per night, MDD - 5 mg treatment is recommended to end the gradual reduction of dimensionless duration of treatment should not exceed 4 weeks, including a period of gradual discontinuation of the drug, continued treatment over this period only after careful re-evaluation of clinical picture. Contraindications to the use dimensionless drugs: hypersensitivity to the drug, severe hepatic failure c-m Sleep apnea, severe DN; severe myasthenia Bipolar Disorder lactation, children's age (18 years). The main pharmaco-therapeutic effects: hypnotic, sedative, anksyolitychna, anticonvulsant action and amnezuyucha and has high selectivity and low affinity for benzodiazepine without pain of the first type, in patients with primary and psychophysiological insomnia, depending on age, on admission zaleplonu 5 mg and 10 mg reduced sleep latency, which runs until filling, prolonged sleep in the first half of the night, while the drug does not affect the percentage ratio between different phases of sleep at 2 - and 4-week no admission of any of the dosage is not formed pharmacological tolerance. Side effects and complications in the use of drugs: daily fatigue, drowsiness, exhaustion, dizziness, disturbance of gait and movements (ataxia), slowing of psychomotor responses, concentrating defect and memory impairment (anterohradna amnesia), the morning after taking the vehicle overnight - pronounced residual fatigue and impaired concentration and attention, muscle weakness, headache, confusion, dry mouth, nausea, vomiting, constipation and slight decrease AT, itching and skin rashes, increased appetite, reduce sex drive in women's dimensionless cycle; weakened breathing (respiratory depression) may occur in patients with stenosis (obstruction) and respiratory tract damage brain, hallucinations and "paradoxical" reaction (increased aggressiveness, G. Pharmacotherapeutic group: N05CF03 - hypnotic agents. (vuzkokutova glaucoma) dimensionless pregnancy and lactation, infancy.
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